Kenneth A Koeplinger: search on Z-Library

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1

Liquid microjunction surface sampling probe electrospray mass spectrometry for detection of drugs and metabolites in thin tissue sections

Gary J. Van Berkel, Vilmos Kertesz, Kenneth A. Koeplinger, Marissa Vavrek, Ah-Ng Tony Kong

Journal:

Journal of Mass Spectrometry

Year:

2008

Language:

english

File:

PDF, 511 KB

english, 2008

2

Stereoselective hydroxylation of nonpeptidic HIV protease inhibitors by CYP2D6

Zhiyang Zhao, Kenneth A. Koeplinger, Daniel J. Waldon

Journal:

Year:

1999

Language:

english

File:

PDF, 251 KB

english, 1999

3

HILIC LC-MS for the determination of 2′-C-methyl-cytidine-triphosphate in rat liver

Vincenzo Pucci, Claudio Giuliano, Rena Zhang, Kenneth Alan Koeplinger, Joseph F. Leone, Edith Monteagudo, Fabio Bonelli

Journal:

Journal of Separation Science

Year:

2009

Language:

english

File:

PDF, 631 KB

english, 2009

4

Chromatographic Measurement of Drug–Protein Interaction: Determination of HIV Protease Inhibitor–Serum Albumin Association

Kenneth A. Koeplinger, Zhiyang Zhao

Journal:

Analytical Biochemistry

Year:

1996

Language:

english

File:

PDF, 129 KB

english, 1996

5

Pyridine containing M1 positive allosteric modulators with reduced plasma protein binding

Scott D. Kuduk, Christina N. Di Marco, Victoria Cofre, Daniel R. Pitts, William J. Ray, Lei Ma, Marion Wittmann, Matthew Seager, Kenneth Koeplinger, Chuck D. Thompson, George D. Hartman, Mark T. Bilod

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 2.57 MB

english, 2010

6

N-Heterocyclic derived M1 positive allosteric modulators

Scott D. Kuduk, Christina N. Di Marco, Victoria Cofre, Daniel R. Pitts, William J. Ray, Lei Ma, Marion Wittmann, Lone Veng, Matthew A. Seager, Kenneth Koeplinger, Charles D. Thompson, George D. Hartma

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.60 MB

english, 2010

7

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators

Feng V. Yang, William D. Shipe, Jaime L. Bunda, M. Brad Nolt, David D. Wisnoski, Zhijian Zhao, James C. Barrow, William J. Ray, Lei Ma, Marion Wittmann, Matthew A. Seager, Kenneth A. Koeplinger, Georg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 2.59 MB

english, 2010

8

Corrigendum to “Pyridine containing M1 positive allosteric modulators with reduced plasma protein binding” [Bioorg. Med. Chem. Lett. 20 (2010) 657]

Scott D. Kuduk, Christina N. Di Marco, Victoria Cofre, Daniel R. Pitts, William J. Ray, Lei Ma, Marion Wittmann, Matthew A. Seager, Kenneth Koeplinger, Charles D. Thompson, George D. Hartman, Mark T.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 102 KB

english, 2010

9

Heterocyclic fused pyridone carboxylic acid M1 positive allosteric modulators

Scott D. Kuduk, Christina N. Di Marco, Ronald K. Chang, William J. Ray, Lei Ma, Marion Wittmann, Matthew A. Seager, Kenneth A. Koeplinger, Charles D. Thompson, George D. Hartman, Mark T. Bilodeau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 2.06 MB

english, 2010

10

Hydroxy cycloalkyl fused pyridone carboxylic acid M1 positive allosteric modulators

Scott D. Kuduk, Robert M. DiPardo, Douglas C. Beshore, William J. Ray, Lei Ma, Marion Wittmann, Matthew A. Seager, Kenneth A. Koeplinger, Charles D. Thompson, George D. Hartman, Mark T. Bilodeau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 808 KB

english, 2010

11

Fused heterocyclic M1 positive allosteric modulators

Scott D. Kuduk, Christina N. Di Marco, Victoria Cofre, William J. Ray, Lei Ma, Marion Wittmann, Matthew A. Seager, Kenneth A. Koeplinger, Charles D. Thompson, George D. Hartman, Mark T. Bilodeau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 834 KB

english, 2011

12

Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series

Scott D. Kuduk, Ronald K. Chang, Christina N. Di Marco, William J. Ray, Lei Ma, Marion Wittmann, Matthew A. Seager, Kenneth A. Koeplinger, Charles D. Thompson, George D. Hartman, Mark T. Bilodeau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.48 MB

english, 2011

13

High-performance liquid chromatographic separation of peptides on a diol-gly-phe-phe tripeptide-bonded phase

Thomas C. Pinkerton, Kenneth A. Koeplinger

Journal:

Journal of Chromatography A

Year:

1988

Language:

english

File:

PDF, 1.28 MB

english, 1988

14

Equilibrium distribution of HIV antiviral drugs into human peripheral blood mononuclear cells (PBMC) is controlled by free drug concentration in the extracellular medium

Kenneth A Koeplinger, Thomas J Raub, Guy E Padbury, Zhiyang Zhao

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

1999

Language:

english

File:

PDF, 161 KB

english, 1999

15

Cyclic phosphoramidates as prodrugs of 2′-C-methylcytidine

Malte Meppen, Barbara Pacini, Renzo Bazzo, Uwe Koch, Joseph F. Leone, Kenneth A. Koeplinger, Michael Rowley, Sergio Altamura, Annalise Di Marco, Fabrizio Fiore, Claudio Giuliano, Odalys Gonzalez-Paz,

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 270 KB

english, 2009

16

Administration of a HepDirect™ Prodrug of 2′-C-methylcytidine to Hepatitis C Virus Infected Chimpanzees

Steven Carroll, Kenneth Koeplinger, Marissa Vavrek, Laurence Handt, Malcolm MacCoss, Scott Hecker, David Olsen

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 77 KB

english, 2009

17

The atomic-resolution structure of human caspase-8, a key activator of apoptosis

William Watt, Kenneth A Koeplinger, Ana M Mildner, Robert L Heinrikson, Alfredo G Tomasselli, Keith D Watenpaugh

Journal:

Year:

1999

Language:

english

File:

PDF, 197 KB

english, 1999

18

[W206R]-Procaspase 3: An Inactivatable Substrate for Caspase 8

Kenneth B. Rank, Ana M. Mildner, Joseph W. Leone, Kenneth A. Koeplinger, K.C. Chou, Alfredo G. Tomasselli, Robert L. Heinrikson, Satish K. Sharma

Journal:

Protein Expression and Purification

Year:

2001

Language:

english

File:

PDF, 799 KB

english, 2001

19

Contribution of serum protein association to discrepancy between the in vivo and in vitro UDS results for 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843)

Zhiyang Zhao, Kenneth A Koeplinger, Guy E Padbury, Charles S Aaron, Philip R Harbach, Judy K Mayo, William B Mattes, Gordon L Bundy

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

1997

Language:

english

File:

PDF, 139 KB

english, 1997

20

Caspase 8: An Efficient Method for Large-Scale Autoactivation of Recombinant Procaspase 8 by Matrix Adsorption and Characterization of the Active Enzyme

Kenneth A. Koeplinger, Ana M. Mildner, Joseph W. Leone, Jean S. Wheeler, Robert L. Heinrikson, Alfredo G. Tomasselli

Journal:

Protein Expression and Purification

Year:

2000

Language:

english

File:

PDF, 189 KB

english, 2000

21

Identification of Amides as Carboxylic Acid Surrogates for Quinolizidinone-Based M 1 Positive Allosteric Modulators

Kuduk, Scott D., Chang, Ronald K., Greshock, Thomas J., Ray, William J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 369 KB

english, 2012

22

Synthesis and dimerization of two cross-conjugated trienes: 3-methylene-1,4-pentadiene and 1,2,3-trimethylenecyclohexane

Trahanovsky, Walter S., Koeplinger, Kenneth A.

Journal:

Journal of Organic Chemistry

Year:

1992

Language:

english

File:

PDF, 856 KB

english, 1992

23

Quinolizidinone Carboxylic Acids as CNS Penetrant, Selective M 1 Allosteric Muscarinic Receptor Modulators

Kuduk, Scott D., Chang, Ronald K., Di Marco, Christina N., Ray, William J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, M

Journal:

ACS Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.08 MB

english, 2010

24

Comparison of Drug Distribution Images from Whole-Body Thin Tissue Sections Obtained Using Desorption Electrospray Ionization Tandem Mass Spectrometry and Autoradiography

Kertesz, Vilmos, Van Berkel, Gary J., Vavrek, Marissa, Koeplinger, Kenneth A., Schneider, Bradley B., Covey, Thomas R.

Journal:

Analytical Chemistry

Year:

2008

Language:

english

File:

PDF, 574 KB

english, 2008

25

Bioactivation of 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7 H -pyrrolo[2,3- d ]pyrimidine (U-89843) to Reactive Intermediates That Bind Covalently to Macromolecules and Produce Genotoxicity 1

Zhao, Zhiyang, Koeplinger, Kenneth A., Padbury, Guy E., Hauer, Michael J., Bundy, Gordon L., Banitt, Lee S., Schwartz, Theresa M., Zimmermann, David C., Harbach, Philip R., Mayo, Judy K., Aaron, C. Si

Journal:

Chemical Research in Toxicology

Year:

1996

Language:

english

File:

PDF, 386 KB

english, 1996

26

Determination of warfarin-human serum albumin protein binding parameters by an improved Hummel-Dreyer high-performance liquid chromatographic method using internal surface reversed-phase columns

Pinkerton, Thomas C., Koeplinger, Kenneth A.

Journal:

Analytical Chemistry

Year:

1990

Language:

english

File:

PDF, 2.13 MB

english, 1990

27

Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M1 positive allosteric modulators

Kuduk, Scott D., Di Marco, Christina N., Saffold, Jonathan R., Ray, William J., Ma, Lei, Wittmann, Marion, Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark T., Beshore,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.24 MB

english, 2014

28

Molecular Dynamics Simulations of 4-Component Membranes with Novel Cationic Lipids Yield Insight into Apoe Binding

Feuston, Bradley P., Colletti, Steven, Culberson, Christopher, Gindy, Marian, Koeplinger, Kenneth, Stanton, Mathew

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 41 KB

english, 2014

29

Discovery of Naphthyl-Fused 5-Membered Lactams as a New Class of M 1 Positive Allosteric Modulators

Yang, Zhi-Qiang, Shu, Youheng, Ma, Lei, Wittmann, Marion, Ray, William J., Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark T., Kuduk, Scott D.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 512 KB

english, 2014

30

Discovery of a Selective Allosteric M 1 Receptor Modulator with Suitable Development Properties Based on a Quinolizidinone Carboxylic Acid Scaffold

Kuduk, Scott D., Chang, Ronald K., Di Marco, Christina N., Pitts, Daniel R., Greshock, Thomas J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman,

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

31

Liver-Targeted Prodrugs of 2‘- C -Methyladenosine for Therapy of Hepatitis C Virus Infection

Hecker, Scott J., Reddy, K. Raja, van Poelje, Paul D., Sun, Zhili, Huang, Wenjian, Varkhedkar, Vaibhav, Reddy, M. Venkat, Fujitaki, James M., Olsen, David B., Koeplinger, Kenneth A., Boyer, Serge H.,

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 128 KB

english, 2007

32

Impact of pH on Plasma Protein Binding in Equilibrium Dialysis

Kochansky, Christopher J., McMasters, Daniel R., Lu, Ping, Koeplinger, Kenneth A., Kerr, Haley H., Shou, Magang, Korzekwa, Kenneth R.

Journal:

Molecular Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 1022 KB

english, 2008

33

Disposition of Vorinostat, A Novel Histone Deacetylase Inhibitor and Anticancer Agent, in Preclinical Species

Sandhu, Punam, Andrews, Paul, Baker, Maribeth, Koeplinger, Kenneth, Soli, Eric, Miller, Thomas, Baillie, Thomas

Journal:

Drug Metabolism Letters

Year:

2007

Language:

english

File:

PDF, 232 KB

english, 2007

34

Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry

Lagrutta, Armando, Regan, Christopher P., Zeng, Haoyu, Imredy, John P., Koeplinger, Kenneth, Morissette, Pierre, Liu, Liping, Wollenberg, Gordon, Brynczka, Christopher, Lebrón, José, DeGeorge, Joseph,

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.73 MB

english, 2017

35

MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate

Beshore, Douglas C., N. Di Marco, Christina, Chang, Ronald K., Greshock, Thomas J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Fuerst, Joy, Hartman, G

Journal:

ACS Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 331 KB

english, 2018

36

Polyethlyene Glycol 200 can Protect Rats against Drug-Induced Kidney Toxicity through Inhibition of the Renal Organic Anion Transporter 3

Gu, Yi-Zhong, Chu, Xiaoyan, Houle, Robert, Vlasakova, Katerina, Koeplinger, Kenneth A, Bourgeois, Isabelle, Palyada, Kiran, Anderson, Kenneth D, Brynczka, Christopher, Bhatt, Bhavana, Chen, Feifei, Sm

Journal:

Toxicological Sciences

Year:

2019

Language:

english

File:

PDF, 1.97 MB

english, 2019